5-Amino-1MQ

Chemical & Structural Information

• Compound type: Small-molecule NNMT inhibitor; not a peptide
• Common research form: 5-amino-1-methylquinolinium iodide
• CAS Number: 42464-96-0 for the iodide salt
• Molecular Formula: C10H11IN2
• Molecular Weight: approximately 286.11 g/mol

What It Is

5-Amino-1MQ is a small research molecule designed to block an enzyme called NNMT. NNMT is connected with
nicotinamide, NAD biology, methyl-group use and fat-cell metabolism.

Research Focus

• NNMT - researchers study what happens when this enzyme is blocked.
• Fat cells - animal and cell studies examine effects on adipocyte metabolism.
• NAD-related biology - NNMT uses nicotinamide, which is linked to pathways that also affect NAD+.
• Metabolic research - studies explore energy use, body-fat biology and related markers in experimental models.
How It Is Studied
5-Amino-1MQ is studied as an NNMT inhibitor. Blocking NNMT changes how cells process nicotinamide and methyl
groups, which can affect wider metabolic pathways.

Glossary

• NNMT: An enzyme that changes nicotinamide by adding a methyl group.
• Inhibitor: A substance that reduces or blocks an enzyme or receptor.
• Nicotinamide: A form of vitamin B3 used in NAD-related biology.
• Adipocyte: A fat cell.

For Research Purposes Only