MOTS-C

Chemical & Structural Information

• Compound type: 16-amino-acid mitochondrial-derived peptide
• CAS Number: 1627580-64-6
• Molecular Formula: C101H152N28O22S2
• Molecular Weight: approximately 2,174.6 g/mol
• Peptide Sequence: MRWQEMGYIFYPRKLR

What It Is

MOTS-c is a 16-amino-acid peptide encoded by mitochondrial genetic material. Researchers study it as a possible
messenger between mitochondria, energy-sensing pathways and the cell nucleus.
Research Focus
• Energy sensing - MOTS-c is strongly linked with AMPK research.
• Glucose metabolism - cell and animal studies look at glucose use and insulin-related signalling.
• Exercise research - studies examine metabolic stress, activity and energy demand.
• Aging biology - research also explores physical capacity and metabolic resilience with age.

How It Is Studied

MOTS-c is unusual because it comes from mitochondrial DNA. Under some conditions it can move into the nucleus
and influence gene activity, linking mitochondrial stress with wider cell responses.
Glossary
• Mitochondrial DNA: Genetic material found inside mitochondria.
• AMPK: A cell enzyme that senses low energy.
• Nuclear translocation: Movement of a molecule into the cell nucleus.
• Metabolism: The chemical processes cells use to make and use energy.

For Research Purposes Only