PT-141 (Bremelanotide)

Chemical & Structural Information

• Compound type: Cyclic melanocortin peptide agonist
• CAS Number: 189691-06-3
• Molecular Formula: C50H68N14O10
• Molecular Weight: approximately 1,025.2 g/mol
• Structure: Cyclic seven-amino-acid melanocortin peptide.

What It Is

PT-141, also called bremelanotide, is a cyclic peptide that activates melanocortin receptors. It has been studied
mainly for signalling in the brain linked with sexual arousal, motivation and behaviour.

Research Focus

• Melanocortin receptors - PT-141 activates receptors in this signalling family.
• Brain signalling - research focuses especially on central nervous system pathways.
• Sexual-arousal research - human clinical research has examined this pathway.
• Peptide design - its ring-shaped structure was developed to change stability and receptor activity.

How It Is Studied

PT-141 acts mainly through melanocortin receptor signalling rather than by directly changing blood flow. MC4R is
one of the main receptors studied in relation to its central effects.

Glossary

• Melanocortin: A family of natural signalling molecules and receptors.
• Cyclic peptide: A peptide whose chain is joined into a ring.
• Agonist: A molecule that activates a receptor.
• Central nervous system: The brain and spinal cord.

For Research Purposes Only