Retatrutide

Chemical & Structural Information

• Compound type: Investigational synthetic peptide; GLP-1/GIP/glucagon triple agonist
• CAS Number: 2381089-83-2
• Molecular Formula: C221H342N46O68
• Molecular Weight: approximately 4,731 g/mol
• Structure: Modified 39-amino-acid peptide with a lipid side chain.

What It Is

Retatrutide is an investigational peptide designed to activate the GLP-1, GIP and glucagon receptors together.
Researchers are studying how this three-part signalling approach affects appetite, glucose handling, energy use and
body weight.

Research Focus

• Appetite signalling - GLP-1 and related pathways are linked with fullness and food intake.
• Glucose control - clinical trials measure insulin, fasting glucose and HbA1c.
• Body-weight research - Phase 2 studies reported substantial average weight changes in some dose groups.
• Broader metabolism - research also measures blood pressure, blood fats, waist size and liver fat.

How It Is Studied

Each receptor has a different job. GLP-1 and GIP mainly support meal-related metabolic signalling, while glucagon
affects liver energy use and fat metabolism. Retatrutide is designed to combine these signals.

Glossary

• Receptor: A protein that receives a signal and starts a response.
• Agonist: A substance that activates a receptor.
• Lipid: A scientific word for fat.
• Hepatic: Related to the liver.

For Research Purposes Only